purB [2017-8-11 16:0:3]

adenylsuccinate lyase

Locus: BSU06440

Isoelectric point: 5.82

Molecular weight: 49.32 kDa

Protein length: 431 aa

Gene length: 1293 bp

Function: purine biosynthesis

Product: adenylsuccinate lyase

Essential: no

E.C.: 4.3.2.2

Synonyms

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Biosynthesis/ acquisition of purine nucleotides
• Information processing → Genetics → Newly identified competence genes

Gene

Coordinates: 700,232 → 701,527

The protein

Catalyzed reaction/ biological activity

• N(6)-(1,2-dicarboxyethyl)AMP = fumarate AMP (according to Swiss-Prot)

Protein family

• Adenylosuccinate lyase subfamily (according to Swiss-Prot)

Structure

• 1F1O

Additional information

• subject to Clp-dependent proteolysis upon glucose starvation PubMed
• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: purE-purK-purB-purC-purS-purQ-purL-purF-purM-purN-purH-purD
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • G-box: termination, (riboswitch) PubMed, in G-box
  • PurR: repression, (molecular inducer: PRPP) PubMed, in PurR regulon

  Regulation

  • expression activated by glucose (4.4 fold) PubMed

References

Loading